Signaling mechanisms in Cellular Homeostasis

The SMICH curriculum focuses on signaling mechanisms and processes involved in the maintenance of cellular and organismal homeostasis. We study the signaling enabling stem and immune cells to make cell fate decisions such as exit/return to quiescence, considering a wider range of post-transcriptional mechanisms and proteome remodeling.


Module 1 - Investigating signaling in health and disease

  • Lectures: Signaling pathways in health and disease
  • Targeted and genome-wide approaches for the discovery and understanding of signaling processes
  • Workshops: Mouse Models & Histology
  • Viral vector delivery and genome engineering
  • Advanced confocal laser scanning microscopy and live cell imaging

Module 2 - Calibrating responses

  • Lectures:  Pluripotency, self-renewal and differentiation
  • Balancing gene expression in stress
  • Workshops: Handling and manipulating mammalian stem cells

Module 3 - Signaling in space and time

  • Lectures: Biochemical approaches for the understanding of processes integrating signaling with subcellular structures
  • Structural approaches for the understanding of signal transduction in molecular detail
  • Workshops: Molecular Membrane Biology

Module 4 - From wet lab to models

  • Lectures: Introduction to data analysis
  • Mathematical modeling and computer simulation of intracellular mechanisms
  • Workshops: Programming and data analysis
  • Modeling and simulation of membrane-localized and cytoplasmic reaction-diffusion processes

Further information on the syllabus is available here

Organizer: Manuela Baccarini, Registration to courses via cornelia.oppitz(at)