Signaling mechanisms in Cellular Homeostasis
The SMICH curriculum focuses on signaling mechanisms and processes involved in the maintenance of cellular and organismal homeostasis. We study the signaling enabling stem and immune cells to make cell fate decisions such as exit/return to quiescence, considering a wider range of post-transcriptional mechanisms and proteome remodeling.
Syllabus
Module 1 - Investigating signaling in health and disease
Lectures:
- Signaling pathways in health and disease
- Targeted and genome-wide approaches for the discovery and understanding of signaling processes
Workshops:
- Mouse Models & Histology
- Viral vector delivery and genome engineering
- Advanced confocal laser scanning microscopy and live cell imaging
Module 2 - Calibrating responses
Lectures:
- Pluripotency, self-renewal and differentiation
- Balancing gene expression in stress
Workshops:
- Handling and manipulating mammalian stem cells
Module 3 - Signaling in space and time
Lectures:
- Biochemical approaches for the understanding of processes integrating signaling with subcellular structures
- Structural approaches for the understanding of signal transduction in molecular detail
Workshops:
- Advanced Workshop Molecular Membrane Biology
- Protein bioinformatics, biochemistry, and basic strategies in protein expression, purification and quality control
Module 4 - From wet lab to models
Lectures:
- Introduction to data analysis
- Mathematical modeling and computer simulation of intracellular mechanisms
Workshops:
- Programming and data analysis
- Modeling and simulation of membrane-localized and cytoplasmic reaction-diffusion processes
Further information on the syllabus is available here
Organizer: Manuela Baccarini. Registration online via u:find