Integrative Structural Biology

This track offers in-depth, interdisciplinary training in various complementary experimental and computational techniques enabling students to identify, analyse and solve biological problems from a fundamentally structural perspective. Students will beable to address the biological question with a suitable suite/combination of biochemical, biophysical and structural biology techniques and will be able to analyze/read structures and draw structure-function relationships to communicate findings.

Organizer: Kristina Djinovic-Carugo

Current Courses

Winter Semester 2021:

301449 VO Current and advanced topics in structural biology 

301247 SE Modern Concepts in Structural Biology I 

301256 SE Seminar for Structural Biology

Summer Semester 2022:

301901 VO+UE Introduction into 3D cryo electron microscopy

301248 SE Modern Concepts in Structural Biology II

301450 VO Macromolecular Crystallography

301463 VO Biophysical chemistry of macromolecules

301256 SE Seminar for Structural Biology

301461 VO Biomolecular NMR-Spectroskopy

053521 VU Bioinformatics of sequences and structures

301232 VO Computational Structural Biology

Highlights: 

  • Strategies in protein expression, purification and quality control (Lecture and Practicals)  
  • Biophysical Chemistry of Macromolecules (Lecture) 
  • Biochemical and Biophysical Methods (Lecture and Practicals) 
  • Core structural biology methods (Lectures and practicals) (MX, NMR, SAXS, Cryo-EM and cryo-ET)  
  • Structural Computational Biophysics (Lecture and Practicals) 
  • Structural Bioinformatics (Lecture and Practicals) 
  • Structural Validation and Analysis (Lecture and Practicals)