2022

Authors Title Year Journal Name Volume PubMedID DOI
Andreev VI, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, Handler D, Duchek P, Novatchkova M, Baumgartner L, Meixner K, Sienski G, Patel DJ, Brennecke J. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. 2022 Nat Struct Mol Biol. 29(2):130-142 PMID: 35173350 doi: 10.1038/s41594-022-00721-x
Baumgartner L, Handler D, Platzer SW, Yu C, Duchek P, Brennecke J. The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters 2022 Elife 11:e80067 PMID: 36193674 doi: 10.7554/eLife.80067
Boccuni L, Podgorschek E, Schmiedeberg M, Platanitis E, Traxler P, Fischer P, Schirripa A, Novoszel P, Nebreda AR, Arthur JSC, Fortelny N, Farlik M, Sexl V, Bock C, Sibilia M, Kovarik P, Müller M, Decker T. Stress signaling boosts interferon-induced gene transcription in macrophages. 2022 Sci Signal. 15(764):eabq5389 PMID: 36512641 doi: 10.1126/scisignal.abq5389
Bragulat-Teixidor H, Hossain MJ, Otsuka S. Visualizing Nuclear Pore Complex Assembly In Situ in Human Cells at Nanometer Resolution by Correlating Live Imaging with Electron Microscopy. 2022 Methods Mol Biol. 2502:493-512 PMID: 35412258 doi: 10.1007/978-1-0716-2337-4_31
Cibulka  J, Bisaccia  Radisavljević  K, Gudino Carrillo  RM, Köhler A. Assembly principle of a membrane-anchored nuclear pore basket scaffold. 2022 Sci Adv. 8(6):eabl6863 PMID: 35148185 doi: 10.1126/sciadv.abl6863
Clarke MN, Marsoner T, Adell MAY, Ravichandran MC, Campbell CS. Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast 2022 EMBO J.   PMID: 36530167 doi: 10.15252/embj.2022111500
Ctortecka C, Krššáková G, Stejskal K, Penninger JM, Mendjan S, Mechtler K, Stadlmann J. Comparative Proteome Signatures of Trace Samples by Multiplexed Data-Independent Acquisition 2022 Mol Cell Proteomics 21(1):100177 PMID: 34793982 doi: 10.1016/j.mcpro.2021.100177
Ctortecka C, Stejskal K, Krššáková G, Mendjan S, Mechtler K. Quantitative Accuracy and Precision in Multiplexed Single-Cell Proteomics. 2022 Anal Chem. 94(5):2434-2443 PMID: 34967612 doi: 10.1021/acs.analchem.1c04174
Dao P, Hajny S, Mekis R, Orel L, Dinhopl N, Tessmar-Raible K, Nowikovsky K. The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. 2022 Life Sci Alliance 5(9):e202101194 PMID: 35697381 doi: 10.26508/lsa.202101194
de Almeida B, Reiter F, Pagani M, Stark A. DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers. 2022 Nat Genet. 54(5):613-624 PMID: 35551305 doi: 10.1038/s41588-022-01048-5
Dequeker BJH, Scherr MJ, Brandão HB, Gassler J, Powell, S, Gaspar I, Flyamer IM, Lalic A, Tang W, Stocsits R, Davidson IF, Peters JM, Duderstadt KE, Mirny LA, Tachibana K. MCM complexes are barriers that restrict cohesin-mediated loop extrusion. 2022 Nature 606(7912):197-203 PMID: 35585235 doi: 10.1038/s41586-022-04730-0
Didusch S, Madern M, Hartl M, Baccarini M. amica: an interactive and user-friendly web-platform for the analysis of proteomics data 2022 BMC Genomic 23(1):817 PMID: 36494623 doi: 10.1186/s12864-022-09058-7
Eislmayr K, Bestehorn A, Morelli L, Borroni M, Walle LV, Lamkanfi M, Kovarik P. Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection. 2022 Sci Adv. 8(9):eabj7293 PMID: 35235356 doi: 10.1126/sciadv.abj7293
ElMaghraby MF, Tirian L, Senti KA, Meixner K, Brennecke J. A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. 2022 Genetics 220(1):iyab179 PMID: 34718559 doi: 10.1093/genetics/iyab179
Gassler J, Kobayashi W, Gáspár I, Ruangroengkulrith S, Mohanan A, Gómez Hernández L, Kravchenko P, Kümmecke M, Lalic A, Rifel N, Ashburn RJ, Zaczek M, Vallot A, Cuenca Rico L, Ladstätter S, Tachibana K. Zygotic genome activation by the totipotency pioneer factor Nr5a2. 2022 Science 378(6626):1305-1315 PMID: 36423263 doi: 10.1126/science.abn7478
Hendy O, Serebreni L, Bergauer K, Muerdter F, Huber L, Nemčko F, Stark A. Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers. 2022 Mol Cell 82(19):3598-3612.e7 PMID: 36113480 doi: 10.1016/j.molcel.2022.08.019
Hollenstein DM, Veis J, Romanov N, Gérecová G, Ogris E, Hartl M, Ammerer G, Reiter W. PP2A Rts1 antagonizes Rck2-mediated hyperosmotic stress signaling in yeast 2022 Microbiol Res 260:127031 PMID: 35461031 doi: 10.1016/j.micres.2022.127031
Jamge B, Berger F. Diversification of chromatin organization in eukaryotes 2022 Curr Op Cell Biol. 74:1-6 PMID: 34998094 doi: 10.1016/j.ceb.2021.12.002
Jamge B, Lorković ZJ, Axelsson E, Yelagandula R, Akimcheva S, Berger F. Transcriptional activity is shaped by the chromatin landscapes in Arabidopsis 2022 bioRxiv     doi: 10.1101/2022.06.02.494419
Jelenic S, Bindics J, Czermak P, Pillai BR, Ruer M, Holehouse AS, Saha S. Composition can buffer protein dynamics within liquid-like condensates 2022 bioRxiv     doi: 10.1101/2022.05.16.492059
Kellner MJ, Ross JJ, Schnabl J, Dekens MPS, Matl M, Heinen R, Grishkovskaya I, Bauer B, Stadlmann J, Menéndez-Arias L, Straw AD, Fritsche-Polan, R, Traugott M, Seitz T, Zoufaly A, Födinger M, Wenisch C, Zuber J, Pauli A, Brennecke J. A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing 2022 Front Mol Biosci. 9:801309 PMID: 35433827 doi: 10.3389/fmolb.2022.801309
Klaus L, de Almeida BP, Vlasova A, Nemčko F, Schleiffer A, Bergauer K, Hofbauer L, Rath M, Stark A. Systematic identification and characterization of repressive domains in Drosophila transcription factors. 2022 EMBO J.   PMID: 36545802  
Leiendecker L, Neumann T, Jung PS, Cronin SM, Steinacker TL, Schleiffer A, Schutzbier M, Mechtler K, Kervarrec T, Laurent E, Bachiri K, Coyaud E, Murali R, Busam KJ, Itzinger-Monshi B, Kirnbauer R, Cerroni L, Calonje E, Rutten A, Stubenrauch F, Griewank KG, Wiesner T, Obenauf AC. Human papillomavirus 42 drives digital papillary adenocarcinoma and elicits a germ-cell like program conserved in HPV-positive cancers. 2022 Cancer Discov. CD-22-0489 PMID: 36213965 doi: 10.1158/2159-8290.CD-22-0489
Leiendecker L, Jung PS, Obenauf AC. Targeting CD56 with an antibody-drug conjugate in Merkel cell carcinoma. 2022 Brit J Dermatol. 186(2):209-210 PMID: 34817859 doi: 10.1111/bjd.20894.
Levina A, Fleming KD, Burke JE, Leonard TA. Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation. 2022 Nat Commun. 13(1):1874 PMID: 35387990 doi: 10.1038/s41467-022-29368-4
Manakanatas C, Ghadge SK, Agic A, Sarigol F, Fichtinger P, Fischer I, Foisner R, Osmanagic-Myers S. Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeria. 2022 Aging (Albany, NY) 14(1):195-224 PMID: 35020601 doi: 10.18632/aging.203820
Marsoner T, Yedavalli P, Masnovo C, Fink S, Schmitzer K, Campbell CS. Aurora B activity is promoted by cooperation between discrete localization sites in budding yeast. 2022 Mol Biol Cell   PMID: 35704464 doi: 10.1091/mbc.E21-11-0590
Mitter M, Takacs, Z., Köcher, T., Micura, R., Langer, CCH., Gerlich, DW. Sister chromatid-sensitive Hi-C to map the conformation of replicated genomes. 2022 Nat Protoc. 17(6):1486-1517 PMID: 35478248 doi: 10.1038/s41596-022-00687-6
Montgomery SA, Hisanaga T, Wang N, Axelsson N, Akimcheva S, Sramek M, Liu C, Berger F. Viviparity is sufficient for the evolution of genomic imprinting 2022 Elife     doi: 10.7554/eLife.79258
Balbo Pogliano C, Ceppi I, Giovannini S, Petroulaki V, Palmer N, Uliana F, Gatti M, Kasaciunaite K, Freire R, Seidel R, Altmeyer M, Cejka P, Matos J. The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells 2022 Sci Adv. 8(5):eabk0221 PMID: 35119917 doi: 10.1126/sciadv.abk0221
Bangert C, Villazala-Merino S, Fahrenberger M, Krausgruber T, Bauer WM, Stanek V, Campion NJ, Bartosik T, Quint T, Regelsberger G, Niederberger-Leppin V, Bock C, Schneider S, Eckl-Dorna J. Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease. 2022 Front Immunol. 13:850494 PMID: 35418991 doi: 10.3389/fimmu.2022.850494
Butz S, Schmolka N, Karemaker ID, Villaseñor R, Schwarz I, Domcke S, Uijttewaal ECH, Jude J, Lienert F, Krebs AR, de Wagenaar NP, Bao X, Zuber J, Elling U, Schübeler D, Baubec T. DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions. 2022 Nat Genet. 54(11):1702-1710 PMID: 36333500 doi: 10.1038/s41588-022-01210-z
Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, Guilliams M, Alon U, Shalek AK, Hamel R, Pfau SJ, Raj A, Quake SR, Zhang NR, Fan J, Trapnell C, Wang B, Greenwald NF, Vento-Tormo R, Santos SDM, Spencer SL, Garcia HG, Arekatla G, Gaiti F, Arbel-Goren R, Rulands S, Junker JP, Klein AM, Morris SA, Murray JI, Galloway KE, Ratz M, Romeike M. Single cell biology-a Keystone Symposia report 2022 Ann N Y Acad Sci 1506(1):74-97 PMID: 34605044 doi: 10.1111/nyas.14692
Coudevylle N, Banaś B, Baumann V, Schuschnig M, Zawadzka-Kazimierczuk A, Koźmiński W, Martens S. Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway 2022 J Biol Chem. 298(2):101573 PMID: 35007534 doi: 10.1016/j.jbc.2022.101573
Elkrewi M, Khauratovich U, Toups MA, Bett VK, Mrnjavac A, Macon A, Fraisse C, Sax L, Huylmans AK, Hontoria F, Vicoso B. ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp 2022 Genetics 222(2):iyac123 PMID: 35977389 doi: 10.1093/genetics/iyac123
Fasching N, Petržílek J, Popitsch N, Herzog VA, Ameres SL. Transcriptome-Wide Profiling of RNA Stability. 2022 Methods Mol Biol. 2404:311-330 PMID: 34694617 doi: 10.1007/978-1-0716-1851-6_17.
Fuchs P, Drexler C, Ratajczyk S, Eckhart L. Comparative genomics reveals evolutionary loss of epiplakin in cetaceans 2022 Sci Rep. 12(1):1112 PMID: 35064199 doi: 10.1038/s41598-022-05087-0
Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, González F, Domingo-Pedrol P, Gavaldà A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. 2022 Cell Metab. 34(6):857-873.e9 PMID: 35561674 doi: 10.1016/j.cmet.2022.04.009
Glotzer GL, Tardivo P, Tanaka EM.  Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration 2022 eLife 11:e79762. PMID: 35587651 doi: 10.7554/eLife.79762
Hagelkruys A, Horrer M, Taubenschmid-Stowers J, Kavirayani A, Novatchkova M, Orthofer M, Pai TP, Cikes D, Zhuk S, Balmaña M, Esk C, Koglgruber R, Moeseneder P, Lazovic J, Zopf LM, Cronin SJF, Elling U, Knoblich JA, Penninger JM. The HUSH complex controls brain architecture and protocadherin fidelity. 2022 Sci Adv. 8(44):eabo7247 PMID: 36332029 doi: 10.1126/sciadv.abo7247
Hawkins PME, Hoi, DM, Cheung CY, Wang T, Quan D, Sasi VM, Liu DY, Linington RG, Jackson CJ, Oehlers SH, Cook GM, Britton WJ, Clausen T, Payne RJ. Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A 2022 J Med Chem. 65(6):4893-4908 PMID: 35293761 doi: 10.1021/acs.jmedchem.1c02122
Hisanaga T, Romani F, Wu S, Kowar T, Lintermann R, Jamge B, Montgomery SA, Axelsson A, Dierschke T, Bowman JL, Fujiwara T, Hirooka S, Miyagishima S, Dolan L, Schubert D, Berger F. Transposons repressed by H3K27me3 were co-opted as cis-regulatory elements of H3K27me3 controlled protein coding genes during evolution of plants 2022 bioRxiv     doi: 10.1101/2022.10.24.513474
Huth M, Santini L, Galimberti E, Ramesmayer J, Titz-Teixeira F, Sehlke R, Oberhuemer M, Stummer S, Herzog V, Garmhausen M, Romeike M, Chugunova A, Leesch F, Holcik L, Weipoltshammer K, Lackner A, Schoefer C, von Haeseler A, Buecker C, Pauli A, Ameres SL, Smith A, Beyer A, Leeb M. NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation. 2022 Gene Dev. 36(5-6):348-367 PMID: 35241478 doi: 10.1101/gad.347690
Jurado S, Fedl AS, Jaritz M, Kostanova-Poliakova D, Malin  SG, Mullighan CG, Strehl  S, Fischer M, Busslinger M. The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation. 2022 EMBO J. 41(7):e108397 PMID: 35156727 doi: 10.15252/embj.2021108397
Kagawa, H., Javali, A., Heidari Khoei, H., Sommer, TM., Sestini G, Novatchkova, M., Scholte Op Reimer, Y., Rivron, N. Protocol for Human Blastoids Modeling Blastocyst Development and Implantation 2022 J Vis Exp.   PMID: 36036618 doi: 10.3791/63388
Kaiser FMP, Gruenbacher S, Oyaga MR, Nio E, Jaritz M, Sun Q, van der Zwaag W, Kreidl E, Zopf LM, Dalm VASH, Pel J, Gaiser C, van der Vliet R, Wahl L, Rietman A, Hill L, Leca I, Driessen G, Laffeber C, Brooks A, Katsikis PD, Lebbink JHG, Tachibana K, van der Burg M, De Zeeuw CI, Badura A, Busslinger M. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder 2022 J Exp Med. 219(9):e20220498 PMID: 35947077 doi: 10.1084/jem.20220498
Kandolf S, Grishkovskaya I, Belačić K, Bolhuis DL, Amann S, Foster B, Imre R, Mechtler K, Schleiffer A, Tagare HD, Zhong ED, Meinhart A, Brown NG, Haselbach D. Cryo-EM structure of the plant 26S proteasome. 2022 Plant Commun 3(3):100310 PMID: 35576154 doi: 10.1016/j.xplc.2022.100310
Kaplan L, Drexler C, Pfaller AM, Brenna S, Wunderlich KA, Dimitracopoulos A, Merl-Pham J, Perez MT, Schlötzer-Schrehardt U, Enzmann V, Samardzija M, Puig B, Fuchs P, Franze K, Hauck SM, Grosche A. Retinal regions shape human and murine Müller cell proteome profile and functionality 2022 Glia   PMID: 36334068 doi: 10.1002/glia.24283
Lee JH, Kim S, Han S, Min J, Caldwell B, Bamford AD, Rocha ASB, Park J, Lee S, Wu SS, Lee H, Fink J, Pilat-Carotta S, Kim J, Josserand M, Szep-Bakonyi R, An Y, Ju YS, Philpott A, Simons BD, Stange DE, Choi E, Koo BK, Kim JK. p57Kip2 imposes the reserve stem cell state of gastric chief cells 2022 Cell Stem Cell 29(5):826-839.e9 PMID: 35523142 doi: 10.1016/j.stem.2022.04.001
Lugmayr, W., Kotov, V., Goessweiner-Mohr, N., Wald J, DiMaio, F., Marlovits, TC. StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement 2022 Nat Protoc.   PMID: 36323866 doi: 10.1038/s41596-022-00757-9
Mayer RL, Matzinger M, Schmücker A, Stejskal K, Krššáková G, Berger F, Mechtler M. Wide Window Acquisition and AI-based data analysis to reach deep proteome coverage for a wide sample range, including single cell proteomic inputs 2022 bioRxiv     doi: 10.1101/2022.09.01.506203
Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstab, H, Rumpel K, Schmiede, VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen T. BacPROTACs mediate targeted protein degradation in bacteria 2022 Cell 185(13):2338-2353.e18 PMID: 35662409 doi: 10.1016/j.cell.2022.05.009

2021

Authors Title Year Journal Name Volume PubMedID DOI  
Appel LM, Franke V, Bruno M, Grishkovskaya I, Kasiliauskaite A, Kaufmann T, Schoeberl UE, Puchinger MG, Kostrhon S, Ebenwaldner C, Sebesta M, Beltzung E, Mechtler K, Lin G, Vlasova A, Leeb M, Pavri R, Stark A, Akalin A, Stefl R, Bernecky C, Djinovic-Carugo K, Slade D. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC. 2021 Nature Commun. 12(1):6078 PMID: 34667177 doi: 10.1038/s41467-021-26360-2  
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J. The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. 2021 Mol Cell 81(12):2520-2532.e16 PMID: 33930333 doi: 10.1016/j.molcel.2021.04.007  
Balay SD, Hochstoeger T, Vilceanu A, Malkemper EP, Snider W, Dürnberger G, Mechtler K, Schuechner S, Ogris E, Nordmann GC, Ushakova L, Nimpf S, Keays DA. The expression, localisation and interactome of pigeon CRY2 2021 Sci Rep. 11(1):20293 PMID: 34645873 doi: 10.1038/s41598-021-99207-x  
Bente H, Foerster AM, Lettner N, Mittelsten Scheid O. Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure. 2021 PLoS Genet. 17(3):e1009444 PMID: 33690630 doi: 10.1371/journal.pgen.1009444  
Bhat P, Burkard TR, Herzog VA, Pauli A, Ameres SL. Systematic refinement of gene annotations by parsing mRNA 3' end sequencing datasets. 2021 Methods Enzymol. 655:205-223 PMID: 34183122 doi: 10.1016/bs.mie.2021.03.016  
Budroni V, Versteeg GA. Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination. 2021 Viruses 13(4):584 PMID: 33808506 doi: 10.3390/v13040584  
Cabrera-Quio, LE., Schleiffer, A., Mechtler, K., Pauli, A. Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition. 2021 PLoS Genet. 17(2):e1009390 PMID: 33600438 PMID: 33600438  
Cianciulli Sesso A, Lilić B, Amman F, Wolfinger MT, Sonnleitner E, Bläsi U. Gene Expression Profiling of Pseudomonas aeruginosa Upon Exposure to Colistin and Tobramycin. 2021 Front Microbiol. 12:626715 PMID: 33995291 doi: 10.3389/fmicb.2021.626715  
de Almeida M, Hinterndorfer M, Brunner H, Grishkovskaya I, Singh K, Schleiffer A, Jude J, Deswal S, Kalis R, Vunjak M, Lendl T, Imre R, Roitinger E, Neumann T, Kandolf S, Schutzbier M, Mechtler K, Versteeg GA, Haselbach D, Zuber J. AKIRIN2 controls the nuclear import of proteasomes in vertebrates. 2021 Nature 599(7885):491-496 PMID: 34711951 doi: 10.1038/s41586-021-04035-8  
Dello Stritto MR, Bauer B, Barraud P, Jantsch V. DNA topoisomerase 3 is required for efficient germ cell quality control. 2021 J Cell Biol. 220(6):e202012057 PMID: 33798260 doi: 10.1083/jcb.202012057  
Demiroz D, Platanitis E, Bryant M, Fischer P, Prchal-Murphy M, Lercher A, Lassnig C, Baccarini M, Müller M, Bergthaler A, Sexl V, Dolezal M, Decker T Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons. 2021 PLoS Pathog. 17(7):e1009697 PMID: 34237114 doi: 10.1371/journal.ppat.1009697  
Deutschmann-Olek KM, Yue WW, Bezerra GA, Skern T. Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk. 2021 Virology 562:128-141 PMID: 34315103 doi: 10.1016/j.virol.2021.07.008  
Dlugosz P, Teufl M, Schwab M, Kohl KE, Nimpf J. Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. 2021 Int J Mol Sci. 22(4):1745. PMID: 33572344 doi: 10.3390/ijms22041745  
ElMaghraby MF, Tirian L, Senti KA, Meixner K, Brennecke J. A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. 2021 Genetics 220(1):iyab179 PMID: 34718559 doi: 10.1093/genetics/iyab179  
Ferreira I, Lepuschitz S, Beisken S, Fiume G, Mrazek K, Frank BJH, Huber S, Knoll MA, von Haeseler A, Materna A, Hofstaetter JG, Posch AE, Weinberger J. Culture-Free Detection of Antibiotic Resistance Markers from Native Patient Samples by Hybridization Capture Sequencing. 2021 Microorganisms 9(8):1672 PMID: 34442751 doi: 10.3390/microorganisms9081672  
Fuchs A, Riegler S, Ayatollahi Z, Cavallari N, Giono LE, Nimeth BA, Mutanwad KV, Schweighofer A, Lucyshyn D, Barta A, Petrillo E, Kalyna M. Targeting alternative splicing by RNAi: from the differential impact on splice variants to triggering artificial pre-mRNA splicing. 2021 Nucleic Acids Res. 49(2):1133-1151. PMID: 33406240 doi: 10.1093/nar/gkaa1260  
Garbrecht J, Laos T, Holzer E, Dillinger M, Dammermann A. An acentriolar centrosome at the C. elegans ciliary base. 2021 Curr Biol. 31(11):2418-2428.e8. PMID: 33798427 doi: 10.1016/j.cub.2021.03.023  
Gutiérrez-Pérez P, Santillán EM, Lendl T, Wang J, Schrempf A, Steinacker TL, Asparuhova M, Brandstetter M, Haselbach D, Cochella L. miR-1 sustains muscle physiology by controlling V-ATPase complex assembly. 2021 Sci Adv. 7(42):eabh1434 PMID: 34652942 doi: 10.1126/sciadv.abh1434  
Haas L, Elewaut A, Gerard CL, Umkehrer C, Pedersen M, Leiendecker L, Krecioch I, Hoffmann D, Novatchkova M, Kuttke M, Neumann T, Pires de Silva I, Witthock H, Cuendet MA, Carotta S, Harrington KJ, Zuber J, Scolyer RA, Long GV, Wilmott JS, Michielin O, Vanharanta S, Wiesner T, Obenauf AC. Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma. 2021 Nat Cancer 2:693–708      
Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kurzbauer R, Leodolter J, Kukura P, Clausen T. McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. 2021 Elife 10:e63505 PMID: 34328418 doi: 10.7554/eLife.63505  
Hendling M, Barišić I. Computational Design of Multiplex Oligonucleotide-Based Assays 2021 Methods Mol Biol. 2189:19-30 PMID: 33180290 doi: 10.1007/978-1-0716-0822-7_2  
Hofbauer P, Jahnel SM, Mendjan S. In vitro models of the human heart. 2021 Development 148(16):dev199672 PMID: 34423833 doi: 10.1242/dev.199672  
Hofbauer P, Jahnel SM, Papai N, Giesshammer M, Deyett A, Schmidt C, Penc M, Tavernini K, Grdseloff N, Meledeth C, Ginistrelli LC, Ctortecka C, Šalic Š, Novatchkova M, Mendjan S. Cardioids reveal self-organizing principles of human cardiogenesis. 2021 Cell 184(12):3299-3317.e22 PMID: 34019794 doi: 10.1016/j.cell.2021.04.034  
Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM. Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. 2021 EMBO J. e108375 PMID: 34375000 doi: 10.15252/embj.2021108375  
Hollenstein DM, Gérecová G, Romanov N, Ferrari J, Veis J, Janschitz M, Beyer R, Schüller C, Ogris E, Hartl M, Ammerer G, Reiter W. A phosphatase-centric mechanism drives stress signaling response. 2021 EMBO Rep. 2(11):e52476 PMID: 34558777 doi: 10.15252/embr.202152476  
Hollenstein DM, Licheva M, Konradi N, Schweida D, Mancilla H, Mari M, Reggiori F, Kraft C. Spatial control of avidity regulates initiation and progression of selective autophagy 2021 Nat Commun. 12(1):7194 PMID: 34893607 doi: 10.1038/s41467-021-27420-3  
Jenull S, Mair T, Tscherner M, Penninger P, Zwolanek F, Silao FS, de San Vicente KM, Riedelberger M, Bandari NC, Shivarathri R, Petryshyn A, Chauhan N, Zacchi LF, -Landmann SL, Ljungdahl PO, Kuchler K. The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence. 2021 Cell Rep. 36(3):109406 PMID: 34289370 doi: 10.1016/j.celrep.2021  
Kao P, Nodine MD. Application of expansion microscopy on developing Arabidopsis seeds. 2021 Methods Cell Biol. 161:181-195 PMID: 33478689 doi: 10.1016/bs.mcb.2020.06.004  
Kao P, Schon MA, Mosiolek M, Enugutti B, Nodine MD. Gene expression variation in Arabidopsis embryos at single-nucleus resolution. 2021 Development 148(13):dev199589 PMID: 34142712 doi: 10.1242/dev.199589  
Lackner A, Sehlke R, Garmhausen M, Giuseppe Stirparo G, Huth M, Titz-Teixeira F, van der Lelij P, Ramesmayer J, Thomas HF, Ralser M, Santini L, Galimberti E, Sarov M, Stewart AF, Smith A, Beyer A, Leeb M. Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency. 2021 EMBO J. 40(8):e105776 PMID: 33687089 doi: 10.15252/embj.2020105776  
Landskron L, Bonnay F, Burkard TR, Knoblich JA. DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster. 2021 Bio Protoc. 10(21):e3809 PMID: 33659463 doi: 10.21769/BioProtoc.3809  
Madritsch S, Burg A, Sehr EM. Comparing de novo transcriptome assembly tools in di- and autotetraploid non-model plant species. 2021 BMC Bioinformatics 22(1):146 PMID: 33752598 doi: 10.1186/s12859-021-04078-8  
Mateos B, Bernardo-Seisdedos G, Dietrich V, Zalba N, Ortega G, Peccati F, Jiménez-Osés G, Konrat R, Tollinger M, Millet O. Cosolute modulation of protein oligomerization reactions in the homeostatic timescale. 2021 Biophys J. 120(10):2067-2077. PMID: 33794151 doi: 10.1016/j.bpj.2021.03.020  
Mateos B, Holzinger J, Conrad-Billroth C, Platzer G, Żerko S, Sealey-Cardona M, Anrather D, Koźmiński W, Konrat R. Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition. 2021 Biochemistry 60(17):1347-1355 PMID: 33876640 doi: 10.1021/acs.biochem.1c00050  
Miletic S, Fahrenkamp D, Goessweiner-Mohr N, Wald J, Pantel M, Vesper O, Kotov V, Marlovits TC. Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation. 2021 Nat Commun. 12(1):1546 PMID: 33750771 doi: 10.1038/s41467-021-21143-1  
Montgomery SA, Berger F. The evolution of imprinting in plants: beyond the seed. 2021 Plant Reprod. 34(4):373-383 PMID: 33914165 doi: 10.1007/s00497-021-00410-7  
Aniento F, Sánchez de Medina Hernández V, Dagdas Y, Rojas-Pierce M, Russinova E. Molecular mechanisms of endomembrane trafficking in plants. 2021 Plant Cell 34(1):146-173 PMID: 34550393 doi: 10.1093/plcell/koab235.  
Austin SHL, Gabarró-Solanas R, Rigo P, Paun O, Harris L, Guillemot F, Urbán N. Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation. 2021 Development 148(20):dev199629 PMID: 34557919 doi: 10.1242/dev.199629  
Bajaj S, Bagley JA, Sommer C, Vertesy A, Nagumo Wong S, Krenn V, Lévi-Strauss J, Knoblich JA. Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration 2021 EMBO J. 40(23):e108714 PMID: 34661293 doi: 10.15252/embj.2021108714  
Bauer BW, Davidson IF, Canena D, Wutz G, Tang W, Litos G, Horn S, Hinterdorfer P, Peters JM. "Cohesin mediates DNA loop extrusion by a ""swing and clamp"" mechanism. " 2021 Cell 184(21):5448-5464.e22 PMID: 34624221 doi: 10.1016/j.cell.2021.09.016  
Ben-David E, Pliota P, Widen SA, Koreshova A, Lemus-Vergara T, Verpukhovskiy P, Mandali S, Braendle C, Burga A, Kruglyak L. Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species. 2021 Curr Biol. 31(5):990-1001.e5 PMID: 33417886 doi: 10.1016/j.cub.2020.12.013  
Borg M, Papareddy RK, Dombey R, Axelsson E, Nodine MD, Twell D, Berger F. Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis 2021 Elife 10:e61894 PMID: 33491647 doi: 10.7554/eLife.61894  
Bourguet P, Picard CL, Yelagandula R, Pélissier T, Lorković ZJ, Feng S, Pouch-Pélissier MN, Schmücker A, Jacobsen SE, Berger F, Mathieu O. The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation. 2021 Nat Commun. 12(1):2683 PMID: 33976212 doi: 10.1038/s41467-021-22993-5  
Breitenecker K, Homolya M, Luca AC, Lang V, Trenk C, Petrocz, G, Mohrherr J, Horvath J, Moritsch S, Haas, L, Kurnaeva M, Eferl R, Stoiber D, Moriggl R, Bilban M, Obenauf AC, Ferran C, Dome B, Laszlo V, Győrffy B, Dezso K, Moldvay J, Casanova E, Moll HP. Down-regulation of A20 promotes immune escape of lung adenocarcinomas 2021 Sci Transl Med. 13(601):eabc3911 PMID: 34233950 doi: 10.1126/scitranslmed.abc3911  
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M. Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation. 2021 Sci Immunol. 6(61):eabg5003 PMID: 34301800 doi: 10.1126/sciimmunol.abg5003  
Chatzidaki EE, Powell S, Dequeker BJH, Gassler J, Silva MCC, Tachibana K. Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age. 2021 Curr Biol. S0960-9822(21)00905-2 PMID: 34314679 doi: 10.1016/j.cub.2021.06.076  
Colaianni NR, Parys K, Lee HS, Conway JM, Kim NH, Edelbacher N, Mucyn TS, Madalinski M, Law TF, Jones CD, Belkhadir Y, Dang YL. A complex immune response to flagellin epitope variation in commensal communities 2021 Cell Host Microbe 29(4):635-649.e9 PMID: 33713602 doi: 10.1016/j.chom.2021.02.006  
Diesch J, Le Pannérer MM, Winkler R, Casquero R, Muhar M, van der Garde M, Maher M, Herráez CM, Bech-Serra JJ, Fellner M, Rathert P, Brooks N, Zamora L, Gentilella A, de la Torre C, Zuber J, Götze KS, Buschbeck M. Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis. 2021 Nat Commun. 12(1):6060 PMID: 34663789 doi: 10.1038/s41467-021-26258-z  
Endres T, Solvie D, Heidelberger JB, Andrioletti V, Baluapuri A, Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P, Eilers M. Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. 2021 Mol Cell 81(4):830-844.e13 PMID: 33453168 doi: 10.1016/j.molcel.2020.12.035  
Fatalska A, Stepinac E, Richter M, Kovacs L, Pietras Z, Puchinger M, Dong G, Dadlez M, Glover DM. The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication. 2021 eLife 10:e57241 PMID: 33704067 doi: 10.7554/eLife.57241  
Fujihara Y, Herberg S, Blaha A, Panser K, Kobayashi K, Larasati T, Novatchkova M, Theussl HC, Olszanska O, Ikawa M, Pauli A. The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. 2021 Proc Natl Acad Sci USA   PMID: 34556579 doi: 10.1073/pnas.2108777118  
Glaros V, Rauschmeier R, Artemov AV, Reinhardt A, Ols S, Emmanouilid, A, Gustafsson C, You Y, Mirabello C, Björklund ÅK, Perez L, King NP, Månsson R, Angeletti D, Loré K, Adameyko I, Busslinger M, Kreslavsky T. Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response. 2021 Immunity 54(9):2005-2023.e10 PMID: 34525339 doi: 10.1016/j.immuni.2021.08.017  
Gomez-Diaz C, Jonsson G, Schodl K, Deszcz L, Bestehorn A, Eislmayr K, Almagro J, Kavirayani A, Seida M, Fennell LM, Hagelkruys A, Kovarik P, Penninger JM, Ikeda F. The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains. 2021 iScience 24(11):103241. PMID: 34755089 doi: 10.1016/j.isci.2021.103241.  
Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T. HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain 2021 Nat Chem Biol. 17(10):1084-1092 PMID: 34294896 doi: 10.1038/s41589-021-00831-5  
Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM. A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. 2021 J Exp Med. "4 218(1):e20200559" PMID: 32930709 doi: 10.1084/jem.20200559
Isch C, Majneri P, Landrein N, Pivovarova Y, Lesigang J, Lauruol F, Robinson DR, Dong G, Bonhivers M. Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar. 2021 PLoS Pathog. 17(8):e1009329 PMID: 34339455 doi: 10.1371/journal.ppat.1009329  
Iwasaki M, Kajiwara T, Yasui Y, Yoshitake Y, Miyazaki M, Kawamura S, Suetsugu N, Nishihama R, Yamaoka S, Wanke D, Hashimoto K, Kuchitsu K, Montgomery SA, Singh S, Tanizawa Y, Yagura M, Mochizuki T, Sakamoto M, Nakamura Y, Liu C, Berger F, Yamato KT, Bowman JL, Kohchi T. Identification of the sex-determining factor in the liverwort Marchantia polymorpha reveals unique evolution of sex chromosomes in a haploid system. 2021 Curr Biol. 31(24):5522-5532.e7 PMID: 34735792 doi: 10.1016/j.cub.2021.10.023  
Kostan J, Pavšič M, Puž V, Schwarz TC, Drepper F, Molt S, Graewert MA, Schreiner C, Sajko S, van der Ven PFM, Onipe A, Svergun DI, Warscheid B, Konrat R, Fürst DO, Lenarčič B, Djinović-Carugo K. Molecular basis of F-actin regulation and sarcomere assembly via myotilin. 2021 PLoS Biol. 19(4):e3001148 PMID: 33844684 doi: 10.1371/journal.pbio.3001148  
Kotov V, Mlynek G, Vesper O, Pletzer M, Wald J, Teixeira-Duarte CM, Celia H, Garcia-Alai M, Nussberger S, Buchanan SK, Morais-Cabral JH, Loew C, Djinovic-Carugo K, Marlovits TC. In-depth interrogation of protein thermal unfolding data with MoltenProt. 2021 Protein Sci. 30(1):201-217 PMID: 33140490 doi: 10.1002/pro.3986  
Kovarik P, Bestehorn A, Fesselet J. Conceptual Advances in Control of Inflammation by the RNA-Binding Protein Tristetraprolin. 2021 Front Immunol. 12:751313 PMID: 34603339 doi: 10.3389/fimmu.2021.751313  
Krenn, V., Bosone, C., Burkard, TR., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Rilo Christoff, R., Pestana Garcez, P., Mirazimi, A., Knoblich, JA. Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. 2021 Cell Stem Cell 28(8):1362-1379.e7 PMID: 33838105 doi: 10.1016/j.stem.2021.03.004  
Kroupova A, Ackle F, Asanović I, Weitzer S, Boneberg FM, Faini M, Leitner A, Chui A, Aebersold R, Martinez J, Jinek M. Molecular architecture of the human tRNA ligase complex. 2021 Elife 10:e71656. PMID: 34854379 doi: 10.7554/eLife.71656  
Kurzbauer MT, Janisiw MP, Paulin LF, Mota IP, Tomanov K, Krsicka O, von Haeseler A, Schubert V, Schlögelhofer P ATM Controls Meiotic DNA Double-Strand Break Formation and Recombination and Affects Synaptonemal Complex Organization in Plants 2021 Plant Cell 33(5):1633-1656 PMID: 33659989 doi.org/10.1093/plcell/koab045  
Lin TY, Gerber T, Taniguchi-Sugiura Y, Murawala P, Hermann S, Grosser L, Shibata E, Treutlein B, Tanaka EM. Fibroblast dedifferentiation as a determinant of successful regeneration. 2021 Dev Cell 56(10):1541-1551.e6 PMID: 34004152 doi: 10.1016/j.devcel.2021.04.016  
Lüftinger L, Ferreira I, Frank BJH, Beisken S, Weinberger J, von Haeseler A, Rattei T, Hofstaetter JG, Posch AE, Materna A. Predictive Antibiotic Susceptibility Testing by Next-Generation Sequencing for Periprosthetic Joint Infections: Potential and Limitations. 2021 Biomedicines 9(8):910 PMID: 34440114 doi: 10.3390/biomedicines9080910  
Ma J, Liang Z, Zhao J, Wang P, Ma W, Mai KK, Fernandez Andrade JA, Zeng Y, Grujic N, Jiang L, Dagdas Y, Kang BH. Friendly mediates membrane depolarization-induced mitophagy in Arabidopsis 2021 Curr Biol. 31(9):1931-1944.e4 PMID: 33711250 doi: 10.1016/j.cub.2021.02.034  
Malecka EM, Bassani F, Dendooven T, Sonnleitner E, Rozner M, Albanese TG, Resch A, Luisi B, Woodson S, Bläsi U. Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa. 2021 Nucleic Acids Res. 49(12):7075-7087 PMID: 34139006 doi: 10.1093/nar/gkab510